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Toxicology studies of buspirone yielded the following LD50 values: mice, 655 mg/kg; rats, 196 mg/kg; dogs, 586 mg/kg; and monkeys, 356 mg/kg [link widoczny dla zalogowanych] The effect of food upon the bioavailability of buspirone was studied in 8 subjects [link widoczny dla zalogowanych] The patients evaluated in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months [link widoczny dla zalogowanych] BEFORE USING THIS MEDICINE: Some medicines or medical conditions may interact with this medicine [link widoczny dla zalogowanych] In man, approximately 95% of buspirone is plasma protein bound, but other highly bound drugs, e [link widoczny dla zalogowanych] To achieve an opt
imal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed [link widoczny dla zalogowanych] 1 mg, 13 [link widoczny dla zalogowanych] Patients who have previously taken benzodiazepines may be less likely to respond to buspirone than those who have not [link widoczny dla zalogowanych] In clinical pharmacology trials, doses as high as 375 mg/day were administered to healthy male volunteers [link widoczny dla zalogowanych] Grapefruit and grapefruit juice may interact with BuSpar and lead to potentially dangerous effects [link widoczny dla zalogowanych] Post-marketing experience in the US has shown an adverse experie
nce profile similar to that given above [link widoczny dla zalogowanych] The effectiveness of buspirone in long-term use, that is, for more than 3 to 4 weeks, has not been demonstrated in controlled trials [link widoczny dla zalogowanych] Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic [link widoczny dla zalogowanych] Do not take the medication in larger amounts, or take it for longer than recommended by your doctor [link widoczny dla zalogowanych] Follow the directions on your prescription label [link widoczny dla zalogowanych] The efficacy of buspirone has been demonstrate
d in controlled clinical trials of outpatients whose diagnosis roughly corresponds to Generalized Anxiety Disorder (GAD) [link widoczny dla zalogowanych] In a study in normal volunteers, concomitant administration of buspirone and haloperidol resulted in increased serum haloperidol concentrations [link widoczny dla zalogowanych] Be careful if you drive or do anything that requires you to be awake and alert [link widoczny dla zalogowanych] Although it would appear from limited pharmacokinetic and clinical studies that buspirone does not behave differently in the elderly, there is little known about the effects of buspirone in this age group at doses above 30 mg/day [link widoczny dla zalogowanych] The safety of buspirone duri
ng pregnancy and lactation has not been established and, therefore, it should not be used in women of childbearing potential or nursing mothers, unless, in the opinion of the physician, the potential benefits to the patient outweigh the possible hazards to the fetus [link widoczny dla zalogowanych] Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic [link widoczny dla zalogowanych] These tablets have special scored marks on them to make breaking the tablet easy [link widoczny dla zalogowanych] 5 mg (one half of a tablet), or 5 mg (one third of a tablet) [link widoczny dla zalogowanych] Buspirone is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety
[link widoczny dla zalogowanych] Ask your pharmacist any questions you have about this medication, especially if it is new to you [link widoczny dla zalogowanych] , represent akathisia) [link widoczny dla zalogowanych] Although food increases the amount of buspirone that is absorbed, the importance of this effect is not clear [link widoczny dla zalogowanych] Avoid drinking alcohol [link widoczny dla zalogowanych] Generally, long-term sequelae of any drug's use can be identified only after several years of marketing [link widoczny dla zalogowanych] As this dose was approached, the follow
ing symptoms were observed: nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress [link widoczny dla zalogowanych] In a number of studies performed in healthy volunteers, the mean half-life of buspirone ranged from 2 to 3 hours up to approximately 11 hours with considerable variation in individual values [link widoczny dla zalogowanych] It may increase some of the side effects caused by BuSpar [link widoczny dla zalogowanych] Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor [link widoczny dla zalogowanych] Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic
[link widoczny dla zalogowanych] Additional reports have included rare occurrences of allergic reaction, cogwheel rigidity, dystonic reaction, ecchymosis, emotional lability and tunnel vision [link widoczny dla zalogowanych] Buspirone HCl is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety [link widoczny dla zalogowanych] The clinical significance of this finding is not clear [link widoczny dla zalogowanych] These dosages are 160 to 550 times the recommended human daily dose [link widoczny dla zalogowanych] Buspirone does not block the neuronal reuptake of monoamines and, on chronic administration, it does not lead to changes in receptor
density in the models investigated [link widoczny dla zalogowanych] The 30-mg tablet also contains iron oxide [link widoczny dla zalogowanych] e [link widoczny dla zalogowanych] Symptoms of a BuSpar overdose may include nausea, vomiting, dizziness, drowsiness, blurred vision, and stomach pain [link widoczny dla zalogowanych] The patients evaluated in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months [link widoczny dla zalogowanych] 7 mg, and 27
[link widoczny dla zalogowanych] 6 mg, 9 [link widoczny dla zalogowanych] Discuss the use of grapefruit products with your doctor [link widoczny dla zalogowanych] Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding [link widoczny dla zalogowanych] No deaths have been reported in humans either with deliberate or accidental overdosage of buspirone [link widoczny dla zalogowanych] The 15-mg and 30-mg tablets are provided in the DIVIDOSEŽ tablet design [link widoczny dla zalogowanych] Do not this medication if you are allergic to BuSpar, or if you ha
ve used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days [link widoczny dla zalogowanych] Buspirone is metabolized primarily by oxidation, producing several hydroxylated derivatives and a pharmacologically active metabolite, 1-pyrimidinylpiperazine (1-PP) [link widoczny dla zalogowanych] The pharmacokinetics of buspirone in patients with hepatic or renal dysfunction, and in the elderly, has also not been clearly established [link widoczny dla zalogowanych] Do not take this medication for longer than 4 weeks without your doctors advice [link widoczny dla zalogowanych] Do not use this medication with
out telling your doctor if you are breast-feeding a baby [link widoczny dla zalogowanych] Be careful if you drive or do anything that requires you to be awake and alert [link widoczny dla zalogowanych] Do not give this medication to a child younger than 18 years old [link widoczny dla zalogowanych] Therefore, the physician who elects to use buspirone for extended periods should periodically reassess the usefulness of the drug for the individual patient [link widoczny dla zalogowanych] Buspirone has an affinity for brain D(2)-dopamine receptors, where it acts as an antagonist and agonist, and for the 5-HT(1A) receptors, where it acts as an agonist [link widoczny dla zalogowanych] Addition
al monitoring of your dose or condition may be needed if you are taking fluconazole, itraconazole, ketoconazole, or macrolide antibiotics [link widoczny dla zalogowanych] However, in a study of long-term use, 264 patients were treated with buspirone for 1 year without ill effect [link widoczny dla zalogowanych] g [link widoczny dla zalogowanych] However, the mechanism of action of buspirone remains to be fully elucidated [link widoczny dla zalogowanych] Tell your doctor if you are pregnant or plan to become pregnant during treatment [link widoczny dla zalogowanych] You may take BuSpar with or without food but take it the same way each time
[link widoczny dla zalogowanych] Because of the uncontrolled nature of these spontaneous reports, a causal relationship to buspirone treatment has not been determined [link widoczny dla zalogowanych] g [link widoczny dla zalogowanych] Symptoms of benzodiazepine withdrawal may occur when switching persons from antianxiety medications of the benzodiazepine class (see above) to buspirone since buspirone is not a benzodiazepine [link widoczny dla zalogowanych] Buspirone and its metabolites are excreted in milk in rats [link widoczny dla zalogowanych] Thus, the 5-mg tablet can also provide a 2
[link widoczny dla zalogowanych] phenytoin, propranolol and warfarin, are not displaced by buspirone from plasma protein in vitro [link widoczny dla zalogowanych] It also lacks the prominent sedative effect that is associated with more typical anxiolytics [link widoczny dla zalogowanych]